Blar i forfatter "Sobhkhez, Mehrdad"

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    • Composition of exosomes derived from Atlantic salmon (Salmo salar) head kidney leukocytes 

      Strandskog, Guro; Sobhkhez, Mehrdad; Jørgensen, Jorunn B; Iliev, Dimitar Borisov (Conference object; Konferansebidrag, 2015-06-28)
      Exosomes are secreted nanosize vesicles (30−100 nm) derived from multivesicular endosomes. Exosomes are released by different immune cell types, including T- and B-lymphocytes, mast cells and antigen-presenting cells (APCs). The composition of exosomes - including protein and RNA content reflects their endosomal origin and the type of cells that produce them. Mammalian APCs produce large amounts ...

    • MyD88 interacts with interferon regulatory factor (IRF) 3 and IRF7 in Atlantic salmon (Salmo salar): transgenic SsMyD88 modulates the IRF-induced type I interferon response and accumulates in aggresomes 

      Iliev, Dimitar Borisov; Sobhkhez, Mehrdad; Fremmerlid, Kjersti Kongsgården; Jørgensen, Jorunn B (Journal article; Tidsskriftartikkel; Peer reviewed, 2011-10-11)
      Background: MyD88 directly interacts and affects IRF activation in mammals, but no information has been available about lower vertebrates.<p> <p>Results: Transgenic MyD88 interacts with IRF3 and IRF7A/B and modulates the IRF-induced IFN response and accumulates in aggresomes in Atlantic salmon. <p>Conclusion: MyD88 is involved in the regulation of the IRF-induced IFN response in Atlantic ...

    • Secretome Profiling of Atlantic Salmon Head Kidney Leukocytes Highlights the Role of Phagocytes in the Immune Response to Soluble β-Glucan 

      Iliev, Dimitar B.; Strandskog, Guro; Sobhkhez, Mehrdad; Bruun, Jack A.; Jørgensen, Jorunn B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-30)
      b‐Glucans (BG) are glucose polymers which are produced in bacteria and fungi but not in vertebrate organisms. Being recognized by phagocytic leukocytes including macrophages and neutrophils through receptors such as dectin-1 and Complement receptor 3 (CR3), the BG are perceived by the innate immune system of vertebrates as foreign substances known as Pathogen Associated Molecular Patterns (PAMPs). ...

    • Structural and functional characterization of salmon STAT1, STAT2 and IRF9 homologs sheds light on interferon signaling in teleosts 

      Sobhkhez, Mehrdad; Skjesol, Astrid; Thomassen, Ernst Ivan; Iliev, Dimitar Borisov; Sun, Baojian; Robertsen, Børre; Jørgensen, Jorunn B (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
      Mammalian IRF9 and STAT2, together with STAT1, form the ISGF3 transcription factor complex, which is critical for type I interferon (IFN)-induced signaling, while IFNγ stimulation is mediated by homodimeric STAT1 protein. Teleost fish are known to possess most JAK and STAT family members, however, description of their functional activity in lower vertebrates is still scarce. In the present study we ...

    • Studies of JAK/STAT signaling in Atlantic salmon 

      Sobhkhez, Mehrdad (Doctoral thesis; Doktorgradsavhandling, 2014-06-27)
      In mammals the JAK-STAT pathway plays a significant role in mediating the biological activities of both type I and type II IFN, where JAKs are receptor associated kinases and STATs the transcription factors they activate. At the start of this project the knowledge of the JAK-STAT pathway in fish in general was scarce and there were few reports describing the function of any JAK-STAT family member ...

    • Transcriptome analyses of Atlantic salmon muscle genes induced by a DNA vaccine against salmonid alphavirus, the causative agent of salmon pancreas disease (PD) 

      Sobhkhez, Mehrdad; Krasnov, Aleksei; Robertsen, Børre (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-10-01)
      Salmonid alphavirus (SAV) is the causative agent of pancreas disease (PD) in farmed Atlantic salmon. A previous study showed that vaccination of pre-smolt salmon with a plasmid encoding the structural polypeptide of SAV gave protection against infection and development of PD accompanied by production of antibodies against the virus. In the present work we analyzed transcript responses in the muscle ...

    • Transcriptome analysis of plasmid-induced genes sheds light on the role of type I IFN as adjuvant in DNA vaccine against infectious salmon anemia virus 

      Sobhkhez, Mehrdad; Krasnov, Aleksei; Chang, Chia Jung; Robertsen, Børre (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-21)
      A previous study showed that a plasmid expressing IFNa (pIFNa) strongly enhanced protection and antibody production of a DNA vaccine against infectious salmon anemia virus (ISAV) in Atlantic salmon. The vaccine consisted of a plasmid (pHE) expressing the virus hemagglutinin-esterase as an antigen. To increase the understanding of the adjuvant effect of pIFNa, we here compared transcriptome responses ...